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Recommended training usually consists ofan online video review, bench training, and patient hands-on training. However, in looking at the actual studies included in the reviews and themeta-analyses mentioned above using gene sequencing, the current evidence showsthat p53 mutation is associated with poor response to therapy in the case of gastro-intestinal tumors

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Vaughan CA, Singh S, Windle B, Yeudall WA, Frum R, Grossman SR, Deb SP, Deb S (2012)Gain-of-function activity of mutant p53 in lung cancer through up-regulation of receptor pro-tein tyrosine kinase Axl.

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